Asset evaluation

Probability of success before Phase II

Today, go/no-go decisions on oncology programs rest on basic research and cell-line validation. We add what those cannot provide: patient molecular data, read before clinical efficacy data exist.

Traditional framework for target assessment
The traditional target-assessment framework.
Current state

Decisions made on the wrong model

Investment and termination decisions are made on evidence from systems that do not contain a patient. The first patient-level readout arrives years and tens of millions of dollars later.

One minute

The evaluation path, step by step

Translatability of cell-line models, clinical data for similar drugs, monotherapy activity, commercial opportunity. Each step ends in a recommendation or a conclusive experiment.

Our platform

Investability of oncology programs

Our asset evaluation platform quantifies the probability that a program succeeds, using patient molecular data to anticipate clinical outcomes.

In retrospective validation the model predicts clinical trial outcomes from patient molecular data with 90% accuracy. Methodology and cohort details are available on request.

Investability of oncology drug programs
Investability of oncology drug programs: four checks, one probability of success.
Sample reports

Two full target evaluation reports, public and free to read. The format is the same as a commissioned evaluation.

Engagement

What an evaluation delivers

Input

Target, indication, mechanism

Plus any internal data you can share under NDA. Public data alone is sufficient to start.

Output

Target evaluation report

Dependency evidence by tissue, co-dependencies, resistance mechanisms, patient population size and a translational-risk score. Format as in the samples above.

Timeline

Weeks, not quarters

From scoping call to written report. Portfolio-wide reviews are scoped separately.